DNA Crosslinking via Platinum–DNA Adducts

Platinum-induced DNA crosslinking is a critical molecular target exploited by several frontline chemotherapeutic agents. By forming covalent bonds predominantly at guanine residues within nuclear DNA, these drugs create structural distortions that inhibit vital genetic processes. The resulting cytotoxicity underpins their clinical utility against various cancers but also drives research into mechanisms underlying drug resistance and toxicity profiles.

Other names

Platinum-DNA AdductsCisplatin-DNA AdductsCarboplatin-DNA AdductsOxaliplatin-DNA Adducts

Forms covalent adducts with DNA, primarily at guanine N7 positions, leading to intra- and interstrand crosslinks that distort DNA structure and inhibit replication/transcription.