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Target intelligence / Profile preview
DNA cytosine-5 methyltransferase (DNMT)
- Target
- DNMT
- Molecular classification
- Enzyme, Transferase
01
Overview
DNA cytosine-5 methyltransferases (DNMTs) are a family of enzymes that catalyze the transfer of a methyl group to the 5th carbon position of cytosine residues in DNA, resulting in the formation of 5-methylcytosine. This modification is a key epigenetic mark involved in regulating gene expression, maintaining genome stability, and controlling developmental processes. DNMT1 is a maintenance methyltransferase, while DNMT3A and DNMT3B are de novo methyltransferases. Aberrant activity or mutations in these enzymes are associated with various diseases, including cancer and developmental disorders.
- Other names
- DNA (cytosine-5)-methyltransferasem5C-specific DNA methyltransferase
02
Mechanism of action
Catalyzes the transfer of a methyl group to the 5th carbon position of cytosine residues in DNA
03
Biological functions
Epigenetic regulationGene silencingGenome integrityRegulation of gene expressionX-chromosome inactivationGenomic imprintingSuppression of transposable elementsDevelopmental regulationT cell development
04
Disease associations
CancerDevelopmental disorders
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