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Target intelligence / Profile preview
DNA Damage Enhancement via Radiation-Induced Effects (DDE-RIE)
- Target
- DDE-RIE
- Molecular classification
- DDR pathway modulation, Therapeutic strategy, Combination therapy component
01
Overview
DNA damage enhancement via radiation-induced effects refers to strategies that increase the extent or persistence of DNA lesions caused by ionizing radiation, primarily in cancer cells. This involves inhibiting cellular defense mechanisms such as DNA repair pathways (NHEJ, HR, BER, NER) and cell cycle checkpoints, or activating immune responses via cGAS-STING. The goal is to maximize tumor cell death while minimizing harm to normal tissues. Agents like PARP inhibitors, ATM/ATR inhibitors, and topoisomerase inhibitors are used in combination with radiotherapy to achieve this.
- Other names
- RadiosensitizationEnhancement of radiation-induced genetic injuryRadiation response modification
02
Mechanism of action
Inhibition of DNA repair pathways (NHEJ, HR, BER, NER), checkpoint inhibition, activation of cGAS-STING pathway
03
Biological functions
Apoptosis inductionCell cycle arrest disruptionDNA repair inhibitionAnti-tumor immune response activation
04
Disease associations
Cancer
05
Safety considerations
Increased toxicity to normal tissuesDevelopment of resistanceOff-target effectsMyelosuppressionImmunosuppression
06
Interacting drugs
PARP inhibitors
6 more in the full profile.
07
Biomarkers
BRCA mutation statusDDR gene mutationscGAS-STING pathway activationTumor mutational burden
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