DNA damage-regulated autophagy modulator protein 2 (DRAM2)

DNA damage-regulated autophagy modulator protein 2 (DRAM2, also known as TMEM77) is a lysosomal transmembrane protein crucial for the initiation and regulation of autophagy. DRAM2 contributes to p53-mediated cell death and cytoprotective autophagy, and is especially important in retinal photoreceptor cells where it supports their renewal and recycling. Pathogenic biallelic variants in DRAM2 are linked to a rare autosomal recessive retinal dystrophy (DRAM2 retinopathy) manifesting as cone–rod or macular dystrophies, typically with progressive vision loss starting in young to middle adulthood. While implicated in basic cell homeostasis and tumor suppression, DRAM2 is not currently targeted by any therapeutic agents and has no known drug interactions.

Other names

TMEM77Transmembrane protein 77PSEC0031UNQ154/PRO180MGC54289PRO180WWFQ154RP5-1180E21.1CORD21

Not established for any approved or investigational drug Mechanistically, DRAM2 modulates autophagy through lysosomal function and possibly cell death signaling in conjunction with p53