DNA Damage Repair Pathway (DDR)

The DNA damage repair pathway refers to a collection of highly conserved cellular mechanisms that detect, signal, and repair various forms of DNA damage to maintain genomic stability. These pathways are essential for correcting errors or lesions in the DNA that arise from endogenous metabolic processes or exogenous sources such as radiation and chemicals. Failure in these pathways can lead to mutations, genomic instability, cancer development, and other diseases. Key pathways include Direct Reversal, Base Excision Repair (BER), Nucleotide Excision Repair (NER), Mismatch Repair (MMR), Homologous Recombination (HR/HRR), and Non-Homologous End Joining (NHEJ).

Other names

DNA Repair PathwayDNA Damage Response

Varies depending on the specific drug and pathway. Examples include inhibition of DNA repair enzymes, induction of DNA damage, and synthetic lethality.