DNA damage response induction (DDR)

"DNA damage response induction" refers to the activation of multiple cellular pathways upon the detection of DNA damage. The DNA damage response (DDR) encompasses the recognition of DNA lesions, activation of cell cycle checkpoints, recruitment of repair machinery (such as nucleotide excision repair, homologous recombination, nonhomologous end joining), and, if necessary, initiation of apoptosis to prevent propagation of damaged DNA. The DDR involves major protein families, including sensors (e.g., MRN complex), transducers (ATM, ATR kinases), and effectors (p53, Chk1/2, etc.). Targeting the DDR is a major focus in cancer therapeutics, but "DNA damage response induction" itself is not a specific molecule or target; rather, it denotes a functional process with many contributing molecular targets such as ATM, ATR, DNA-PKcs, p53, and others[1][2][3][4][5].

Other names

DNA damage response (DDR)DNA repair pathwayDDR pathway