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DNA Damage via Beta Radiation
- Molecular classification
- DNA, Genomic Material
01
Overview
DNA damage via beta radiation refers to the molecular and cellular effects caused by exposure of DNA to beta particles. The primary mechanism involves the generation of reactive oxygen species (ROS) that induce single-strand breaks (SSBs), double-strand breaks (DSBs), base modifications, and other lesions. Cells respond via DNA repair pathways like BER and NHEJ. Biological consequences range from cell cycle arrest and apoptosis to mutations and genomic instability, relevant in both cancer therapy and radiation toxicity.
- Other names
- Beta-radiation induced DNA damageDNA lesions from beta particlesGenomic damage by beta radiation
02
Mechanism of action
Indirectly via ROS generation and direct ionization causing SSBs, DSBs, base/sugar modifications.
03
Biological functions
Genome integrityCell cycleApoptosisDNA repair
04
Disease associations
CancerGenomic instabilityRadiation toxicity
05
Safety considerations
Normal tissue toxicityGenomic instabilitySecondary cancer developmentOff-target DNA damage
06
Interacting drugs
Beta-emitting radiopharmaceuticals
07
Biomarkers
γ-H2AX foci53BP1 fociPARP activity
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