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Target intelligence / Profile preview
DNA-dependent RNA Polymerase
- Molecular classification
- Enzyme, Polymerase
01
Overview
DNA-dependent RNA polymerase (DdRp) is an essential enzyme that catalyzes the synthesis of an RNA strand complementary to a DNA template. This process, called transcription, is fundamental for gene expression in all living organisms and many viruses. It is a key target for antiviral and antibacterial drugs.
- Other names
- DNA-directed RNA polymeraseDdRpRNA nucleotidyltransferase (DNA-dependent)RNAP
02
Mechanism of action
Inhibition of RNA synthesis
03
Biological functions
TranscriptionGene expressionRNA synthesis
04
Disease associations
InfectionCancer
05
Safety considerations
Potential for off-target effectsDevelopment of resistanceImpact on host cell transcription (for antiviral therapies)
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