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Target intelligence / Profile preview
DNA-dependent RNA polymerase subunit beta (rpoB)
- Target
- rpoB
- Molecular classification
- Enzyme, RNA Polymerase, Transcription factor
01
Overview
The rpoB gene encodes the β subunit of DNA-dependent RNA polymerase (RNAP) in bacteria. This enzyme is essential for transcription, catalyzing the synthesis of RNA from a DNA template using ribonucleoside triphosphates as substrates. The β subunit forms part of the RNAP core enzyme, which is responsible for all cellular mRNA synthesis. Mutations in rpoB confer resistance to rifamycin antibiotics by reducing drug binding affinity, making it a clinically significant marker for multidrug-resistant pathogens.
02
Mechanism of action
Inhibition of RNA polymerase by binding near the active site and blocking RNA elongation.
03
Biological functions
TranscriptionmRNA synthesisGene expression
04
Disease associations
InfectionAntimicrobial resistance
05
Safety considerations
Development of drug resistanceMultidrug-resistant pathogens
06
Interacting drugs
Rifampicin
2 more in the full profile.
07
Biomarkers
Mutations in rpoB associated with rifampicin resistance
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