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DNA-dependent RNA Polymerase (None)

Target: None
Molecular classification: Enzyme, Polymerase

Overview

DNA-dependent RNA polymerase (DdRp) is an essential enzyme that catalyzes the synthesis of an RNA strand complementary to a DNA template. This process, called transcription, is fundamental for gene expression in all living organisms and many viruses. It is a key target for antiviral and antibacterial drugs.

Other names: DNA-directed RNA polymeraseDdRpRNA nucleotidyltransferase (DNA-dependent)RNAP

Mechanism of action

Inhibition of RNA synthesis

Biological functions

TranscriptionGene expressionRNA synthesis

Disease associations

InfectionCancer

Safety considerations

Potential for off-target effectsDevelopment of resistanceImpact on host cell transcription (for antiviral therapies)

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