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DNA-directed RNA Polymerase I (Pol I)

Target: Pol I
Molecular classification: Enzyme, RNA Polymerase

Overview

DNA-directed RNA polymerase I (Pol I) is a multi-subunit enzyme complex responsible for the transcription of ribosomal RNA (rRNA) genes in eukaryotic cells. It catalyzes the synthesis of a large precursor rRNA molecule from a DNA template, which is subsequently processed into mature 18S, 5.8S, and 28S rRNAs (in yeast: 18S, 5.8S, and 25S). These rRNAs are essential components of ribosomes and thus critical for protein synthesis.

Biological functions

TranscriptionRibosomal RNA (rRNA) synthesisRibosome biogenesis

Disease associations

Cancer (dysregulation of ribosome biogenesis)Ribosomopathies

Safety considerations

Potential for off-target effects on other RNA polymerasesToxicity due to disruption of ribosome biogenesis

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