DNA-directed RNA polymerase I subunit F (POLR1F)

DNA-directed RNA polymerase I subunit F (POLR1F) is a core component of the multi-subunit enzyme RNA polymerase I, which is specialized for the transcription of ribosomal RNA (rRNA) genes in the nucleolus[1][2][3]. The enzyme transcribes a single pre-rRNA precursor that is processed into the main rRNA components of the ribosome, thereby playing an essential role in ribosome biogenesis and cellular homeostasis. POLR1F (also known as RPA43 or TWISTNB) forms part of the smaller stalk complex, crucial for assembly and function of the polymerase complex[2][3]. Upregulation or mutation of this subunit and its associated machinery is linked to diseases such as cancer, ribosomopathies, and developmental disorders. Given its central role in cell proliferation and protein synthesis, RNA polymerase I — including its subunits like POLR1F — is a therapeutic target in oncology, with specific small-molecule inhibitors under investigation. Its function and clinical importance make it a key enzyme in both biological regulation and disease processes[2][3].

Other names

DNA-directed RNA polymerase I subunit RPA43RPA43TWISTNBA43Twist neighbor protein

Inhibition of rRNA transcription, Disruption of ribosome biogenesis, Induction of nucleolar stress leading to cell cycle arrest and apoptosis in rapidly dividing cells