DNA-directed RNA polymerase I subunit RPA12 (POLR1H)

DNA-directed RNA polymerase I subunit RPA12 (POLR1H) is a core component of RNA polymerase I, a DNA-dependent enzyme responsible for synthesizing ribosomal RNA precursors in the nucleolus[4][5]. This subunit contains two zinc-binding motifs and facilitates proofreading during transcription by cleaving misincorporated nucleotides, helping maintain transcription fidelity[4][3]. RNA polymerase I-dependent rRNA synthesis is essential for ribosome biogenesis and cell growth, and dysregulation is linked to cancer and congenital disorders known as ribosomopathies[1][2]. POLR1H participates in regulatory pathways controlling cell proliferation and ribosome production and may influence progression in certain cancers and HIV[3]. As a critical enzymatic subunit necessary for cellular homeostasis, POLR1H and the RNA polymerase I complex are considered promising drug targets, especially for anticancer therapies[2][8].

Other names

RNA polymerase I subunit HPOLR1HRPA12ZNRD1hZR14HTEX-6tctex-6A12.2Zinc ribbon domain-containing protein 1HTEX6Rpa12TCTEX6TEX6ZR14

Inhibition of RNA polymerase I activity (blocks rRNA synthesis, affecting cell proliferation, especially in cancer cells)[2]