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Target intelligence / Profile preview
DNA-directed RNA Polymerase II Subunit RPB1 (RPB1)
- Target
- RPB1
- Molecular classification
- Enzyme, Transcription factor, RNA polymerase
01
Overview
DNA-directed RNA polymerase II subunit RPB1 (RPB1) is the largest and catalytic subunit of RNA polymerase II, the enzyme complex responsible for synthesizing messenger RNA (mRNA) and many functional non-coding RNAs in eukaryotes. It is crucial for mRNA precursor synthesis and its CTD serves as a platform for assembly/regulation by various factors during transcription initiation, elongation, termination, and mRNA processing. In certain viral infections, it can act as an RNA-dependent RNA polymerase.
- Other names
- RNA polymerase II subunit B1EC 2.7.7.6DNA-directed RNA polymerase III largest subunit3'-5' exoribonucleasePOLR2A
02
Mechanism of action
Inhibition of RNA Polymerase II activity
03
Biological functions
Transcription initiationTranscription elongationTranscription terminationmRNA precursor synthesisRNA synthesisRegulation of gene expression
04
Disease associations
CancerInfectionOther
05
Safety considerations
Potential for off-target effects due to widespread role in transcriptionInhibition can disrupt essential cellular processes
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