DNA-directed RNA polymerase II subunit RPB11 (RPB11 (or POLR2J))

RNA polymerase II subunit J (RPB11) is part of the core enzyme responsible for transcribing messenger RNA and many small nuclear RNAs in eukaryotes[3]. As a protein component of the 12-subunit RNA polymerase II complex, it interacts with other subunits (notably RPB3 and RPB12) to stabilize the active center and maintain contact between DNA and the nascent RNA strand during transcription[2][3]. The polymerase orchestrates gene expression, responding to developmental and environmental cues by integrating signals through multiple regulatory protein complexes and transcription factors[1][5]. Mutations or inhibition of RNA polymerase II or its subunits disrupt normal transcription, leading to cell death or altered gene expression, which is relevant for cancer therapy and infectious disease drug development[1][4][3].

Other names

RNA polymerase II subunit JPOLR2JRPB11-aRPB11

Inhibition of Pol II enzymatic activity to block mRNA synthesis (e.g., by preventing nucleotide addition or elongation)