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Target intelligence / Profile preview
DNA-directed RNA Polymerase III (Pol III)
- Target
- Pol III
- Molecular classification
- Enzyme, RNA Polymerase
01
Overview
DNA-directed RNA polymerase III (Pol III) is a multi-subunit enzyme responsible for transcribing DNA into various small, non-coding RNAs, including tRNAs, 5S rRNA, and U6 snRNA. It plays essential roles in cellular function, innate immunity, and DNA repair. Pol III is a therapeutic target for diseases involving dysregulated transcription and viral infections.
- Other names
- RNA polymerase IIIPol IIIRNA polymerase C
02
Mechanism of action
Inhibition of RNA Polymerase III activity
03
Biological functions
TranscriptionRNA synthesisInnate immunityDNA repairGene regulation
04
Disease associations
Hypomyelinating leukodystrophyMicrobial infections
05
Safety considerations
Potential for broad transcriptional disruptionImpact on essential cellular processes
06
Interacting drugs
Alpha-amanitin
1 more in the full profile.
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