DNA-directed RNA polymerase III subunit D (POLR3D)

DNA-directed RNA polymerase III subunit D (POLR3D) is a specific peripheral component of RNA polymerase III, which transcribes hundreds of genes encoding small non-coding RNAs, such as tRNAs, 5S rRNA, snRNAs, and miRNAs. POLR3D, in complexes with other polymerase subunits like POLR3E (RPC5), forms the initiation and termination machinery for transcription of these RNAs. It is essential for cell cycle progression, cell survival, and innate immunity, as it acts as a sensor for intracellular DNA, triggering immune defenses against viruses. Disease-associated mutations in POLR3D disrupt these fundamental processes, resulting in disorders of development, neurodegeneration, and increased susceptibility to infection

Other names

RNA polymerase III subunit DDNA-directed RNA polymerase III subunit RPC4RPC4BN51TC53TSBN51RNA polymerase III 47 kDa subunitBN51BN51 (BHK21) temperature sensitivity complementingPolymerase (RNA) III (DNA directed) polypeptide D, 44kDaPolymerase (RNA) III subunit DRPC53 homologtemperature sensitive complementation (tsBN51)

Drugs (experimental or potential) would likely inhibit polymerase activity, block assembly of the Pol III complex, impair transcription of small RNAs needed for cell survival, or modulate immune response by affecting innate DNA sensing