DNA-directed RNA polymerase III subunit F (POLR3F)

DNA-directed RNA polymerase III subunit F (POLR3F, also called RPC6) is a core component of eukaryotic RNA polymerase III, which is a 17-subunit nuclear enzyme complex specialized in the transcription of short non-coding RNAs including tRNAs, 5S rRNA, and U6 snRNA[1][3][6]. The POLR3F subunit, homologous to yeast RPC6, primarily contributes to the formation and stability of the Pol III preinitiation complex and participates in promoter-specific transcription initiation by interacting with other subunits and transcription factors[3]. Pol III and its subunits play essential roles in RNA biology, and misregulation or mutation can lead to diseases such as hypomyelinating leukodystrophy, cancer, and increased susceptibility to viral infections[1][3][5]. POLR3F is an integral target for understanding transcriptional regulation in eukaryotes and a focus of research into novel therapeutics for related genetic and proliferative disorders[5][6].

Other names

RPC6POLR3FRNA polymerase III subunit FDNA-directed RNA polymerase III subunit RPC6

Enzyme inhibition (drugs may inhibit transcription initiation or elongation by interfering with Pol III complex assembly or function[5]) Disrupt disruption of protein–protein interactions within the Pol III subunit complexes