DNA-directed RNA polymerase subunit beta, bacterial-type

DNA-directed RNA polymerase subunit beta, bacterial-type, is a core enzymatic subunit of the bacterial RNA polymerase complex encoded by the rpoB gene[2][6][7]. It forms part of the active center responsible for the catalysis of RNA synthesis during transcription, working in concert with the beta', alpha, and omega subunits to convert DNA sequences into RNA transcripts[2][3][4][5]. The beta subunit is essential for life in bacteria and is directly targeted by antibiotics like rifampicin, making it a crucial focus for antibacterial drug design and resistance profiling[4][3][7].

Other names

RNA polymerase beta subunit, bacterial-typerpoB gene productDNA-dependent RNA polymerase beta subunitRNAP βBeta subunit of bacterial RNA polymerase

Inhibition of RNA polymerase activity by preventing initiation or elongation of RNA synthesis (e.g., rifampicin binds to the beta subunit, blocking the RNA exit tunnel and preventing RNA chain elongation[4][3][7]) Disruption of the formation or function of the transcriptional machinery