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Target intelligence / Profile preview
DNA-directed RNA polymerases I, II, and III subunit RPABC2 (POLR2F)
- Target
- POLR2F
- Molecular classification
- Enzyme, Transcription factor component, Other (multisubunit enzyme complex subunit)
01
Overview
DNA-directed RNA polymerases I, II, and III subunit RPABC2 (POLR2F) is a protein-coding gene encoding the sixth largest subunit shared by all three major eukaryotic RNA polymerases (I, II, III). It is essential for the transcription of DNA into RNA, contributing to the synthesis of mRNA, rRNA precursors, tRNAs, and other non-coding RNAs. This subunit forms part of the polymerase complex’s clamp element that stabilizes the enzyme on the DNA template during transcription. POLR2F is implicated in various chromatin and cellular pathways and mutations have been associated with neurodevelopmental syndromes and cancers.
- Other names
- RNA polymerase II, I and III subunit FDNA-directed RNA polymerases I, II, and III subunit FRPB6RPABC2RPABC14.4RPB14.4POLRFHRBP14.4RPC15DNA-directed RNA polymerase II subunit FRNA polymerase II subunit FPolymerase (RNA) II polypeptide FDNA-directed RNA polymerase II 14.4 kDa polypeptideRNA polymerases I, II, and III subunit ABC2
02
Biological functions
Transcription of DNA into RNASynthesis of messenger RNA (mRNA), ribosomal RNA (rRNA) precursors, and functional non-coding RNAsComponent of RNA polymerases I, II, and IIIStabilization of the transcription complex
03
Disease associations
Peripheral demyelinating neuropathyCentral dysmyelinationWaardenburg syndromeHirschsprung diseaseWaardenburg-Shah syndromeAcrocephalosyndactylyKallmann syndromeCancer (including endometrial, esophageal, urinary bladder cancer, colorectal cancer)Charcot-Marie-Tooth disease
04
Safety considerations
Targeting core transcriptional machinery may lead to broad and severe cellular toxicity, given the essential and ubiquitous nature of RNA polymerase functionMutations are associated with multisystem developmental disorders and several cancer types
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