DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C)

DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) is a protein encoded by the POLR1C gene on chromosome 6 and is a common structural subunit of both RNA polymerase I and III complexes. These multi-subunit enzymes are responsible for the transcription of ribosomal RNA (rRNA; by polymerase I) and both tRNAs and small non-coding RNAs (by polymerase III), which are essential for ribosome assembly and protein synthesis in all living cells. POLR1C is critical for cellular and organismal viability due to its role in RNA biogenesis. Pathogenic mutations in POLR1C are linked to specific syndromic disorders, notably Treacher Collins syndrome 3 and hypomyelinating leukodystrophy, indicating its importance during early embryonic development for craniofacial and nervous system structures.

Other names

AC40DNA-directed RNA polymerase I subunit CDNA-directed RNA polymerases I and III 40 kDa polypeptideDNA-directed RNA polymerases I and III subunit RPAC1polymerase (RNA) I polypeptide Cpolymerase (RNA) I polypeptide C, 30kDapolymerase (RNA) I subunit CRNA polymerase I subunit CRNA polymerases I and III subunit AC1RPA39RPA40RPA5RPAC1RPAC1_HUMANRPC40TCS3