DNA Double-Strand Breaks (DSBs) (DSBs)

DNA double-strand breaks (DSBs) are critical lesions in the genome resulting from various endogenous and exogenous factors, including ionizing radiation like alpha particles. They involve the breakage of both DNA strands and can lead to genomic instability, cell death, or mutations if not properly repaired. DSBs are targets for cancer therapy, either directly through DNA damaging agents or indirectly through inhibition of repair pathways. However, inappropriate targeting or misrepair of DSBs can also contribute to adverse effects and therapy resistance.

Other names

Double-Strand BreaksDNA breaksDSB

Induction of DNA double-strand breaks through various mechanisms, including direct DNA damage, inhibition of repair pathways, or generation of reactive oxygen species.