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Target intelligence / Profile preview
DNA fragmentation factor subunit alpha (DFFA)
- Target
- DFFA
- Molecular classification
- Apoptosis regulator, Protein complex subunit, Other
01
Overview
DNA fragmentation factor subunit alpha (DFFA) is a regulatory protein encoded by the DFFA gene. It is a key component of the DNA fragmentation factor (DFF) complex, which functions as a heterodimer of a 45-kDa regulatory subunit (DFFA) and a 40-kDa subunit with endonuclease activity (DFFB). DFFA acts as an inhibitor of the caspase-activated DNase (DFFB/CAD) until it is cleaved by caspase-3 during apoptosis. Upon cleavage, DFFA releases DFFB, which then digests chromosomal DNA into nucleosomal fragments, a hallmark of apoptosis. DFFA is therefore central to the execution phase of apoptosis, linking caspase activation to DNA fragmentation and chromatin condensation[1][2][3][8].
- Other names
- DFFADFF-45DFF1ICADDNA fragmentation factor 45 kDa subunitInhibitor of caspase-activated DNaseInhibitor of CADDNA fragmentation factor, 45 kD, alpha subunit
02
Biological functions
ApoptosisRegulation of cell deathInhibition of endonuclease activityChromatin condensationDNA fragmentation
03
Disease associations
CancerNeurodegenerative diseaseCardiovascular disease (e.g., listed in relation to Basilar Artery Occlusion and Intracranial Arteriosclerosis)Other
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