DNA fragmentation factor subunit beta pseudogene 1 (DFFBP1)

DNA fragmentation factor subunit beta pseudogene 1 (DFFBP1) is a processed pseudogene related to the DNA fragmentation factor subunit beta gene (DFFB), which encodes a protein critical for caspase-activated DNA fragmentation during apoptosis. As a pseudogene, DFFBP1 does not encode a functional protein product, nor does it have a demonstrated physiological, pathological, or therapeutic role. Unlike its parent gene DFFB, which is a true functional endonuclease (caspase-activated DNase), DFFBP1 is considered non-functional; its clinical or biological relevance is negligible unless further evidence arises indicating a regulatory noncoding RNA role, which is not currently documented for this locus. Existing data indicate that most such pseudogenes do not represent therapeutic targets, nor do they yield clinically relevant biomolecules.

Other names

DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) pseudogeneDNA fragmentation factor, 40kDa, beta polypeptide pseudogene 1DFFBP1