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Target intelligence / Profile preview
DNA Helicase-Primase Complex (H-P Complex)
- Target
- H-P Complex
- Molecular classification
- Enzyme Complex, Helicase, Primase
01
Overview
The DNA helicase–primase complex is a multi-protein assembly essential for the replication of double-stranded DNA in various organisms, notably in herpesviruses. This complex coordinates two critical enzymatic activities at the replication fork: unwinding duplex DNA (helicase activity) and synthesizing short RNA primers required for DNA polymerases to initiate synthesis. It is an established antiviral drug target.
- Other names
- Helicase-PrimaseUL5-UL52-UL8 complex (HSV-1)BBLF4-BSLF1-BBLF2/3 complex (EBV)
02
Mechanism of action
Blocks helicase and/or primase activity, inhibiting viral DNA replication.
03
Biological functions
DNA replicationDNA unwindingRNA primer synthesisGenome duplication
04
Disease associations
Infection
05
Safety considerations
Potential for drug resistance mutationsOff-target effects on cellular DNA replication
06
Interacting drugs
Amenamevir
3 more in the full profile.
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