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Target intelligence / Profile preview
DNA-histone H1 Complex (H1-DNA)
- Target
- H1-DNA
- Molecular classification
- Nucleoprotein complex, Chromatin component
01
Overview
The DNA-histone H1 complex refers to the molecular assembly formed when histone H1, a linker histone protein, binds to nucleosomal DNA. Histone H1 binds at the entry and exit sites of DNA on the nucleosome and interacts with linker DNA between adjacent nucleosomes. This interaction is crucial for stabilizing higher-order chromatin structures, regulating gene expression, and influencing epigenetic processes.
02
Mechanism of action
N/A
03
Biological functions
Chromatin compactionChromosome stabilizationGene regulationEpigenetic modulationRegulation of gene accessibility
04
Disease associations
CancerDevelopmental disorders
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