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Target intelligence / Profile preview
DNA in Tumor Cells at Sites of Bone Metastasis
- Molecular classification
- Nucleic Acid, DNA, Nuclear DNA, Mitochondrial DNA
01
Overview
DNA within tumor cells at sites of bone metastasis exhibits unique genetic alterations (both nuclear and mitochondrial) that contribute to metastatic behavior. These alterations can serve as biomarkers for disease detection, prognosis, and monitoring response to therapy. Analysis of circulating tumor DNA (ctDNA) and disseminated tumor cells (DTCs) provides insights into the mechanisms underlying skeletal colonization by cancers and informs the development of targeted therapies and risk-adaptive treatment strategies.
02
Biological functions
Genome maintenanceGene expressionEncoding heritable informationTumor cell survivalMetastasis
03
Disease associations
CancerBone MetastasisBreast CancerProstate CancerMinimal Residual Disease
04
Safety considerations
Genetic heterogeneity limits broad applicability of targeted therapiesPotential for off-target effects in gene editing approachesTumor evolution and resistance mechanisms
05
Biomarkers
ctDNA mutationsDTC enumerationSomatic mutations in bone metastasesMitochondrial DNA mutations (e.g., A10398G)tRNA mutations (e.g., tRNA Arg np10436)
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