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Target intelligence / Profile preview
DNA Methylation (DNAm)
- Target
- DNAm
- Molecular classification
- Epigenetic Modification
01
Overview
DNA methylation is an epigenetic modification involving the addition of a methyl group to DNA, typically at cytosine residues. This process plays crucial roles in gene regulation, development, and disease. It is catalyzed by DNA methyltransferases (DNMTs) and can be reversed by demethylation pathways. Aberrant DNA methylation patterns are associated with various diseases, making it a target for epigenetic therapies.
- Other names
- 5-Methylcytosine5mCN6-Methyladenine6mAN4-Methylcytosine4mC
02
Mechanism of action
Targeting DNA methyltransferases (DNMTs) to alter methylation patterns.
03
Biological functions
Gene regulationDevelopmental processesGenomic imprintingX-chromosome inactivationTissue differentiationSuppression of transposable elements
04
Disease associations
CancerAgingOther
05
Safety considerations
Off-target effectsUnintended consequences on gene expressionToxicity related to demethylating agents
06
Biomarkers
Methylation status of specific genesGlobal methylation levels
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