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DNA Methylation at the MYC Locus
- Molecular classification
- Histone modification, Epigenetic modification
01
Overview
DNA methylation at the MYC locus refers to the addition of methyl groups, typically to cytosine bases in CpG dinucleotides, within or near the genomic region encoding the MYC gene. Aberrant DNA methylation patterns at this locus are implicated in cancer development and progression. Changes in DNA methylation can modulate MYC expression levels, impacting cell growth, proliferation, differentiation, and apoptosis.
- Other names
- MYC Locus MethylationMYC methylationMethylation of MYC
02
Mechanism of action
Modulation of gene expression through alteration of DNA methylation patterns
03
Biological functions
Gene regulationRegulation of MYC expressionCell proliferationApoptosisChromatin remodeling
04
Disease associations
CancerProstate cancerHematologic malignancies
05
Safety considerations
Off-target effects of epigenetic drugsPotential for unintended gene expression changes
06
Interacting drugs
DNMT inhibitors
07
Biomarkers
MYC exon 3 CpG site methylationPRNCR1 expression
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