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DNA Methyltransferase (None)
- Target
- None
- Molecular classification
- Enzyme, Transferase
01
Overview
DNA methyltransferases (DNMTs) are a family of enzymes that catalyze the transfer of a methyl group to DNA, primarily at cytosine or adenine bases. This process uses S-adenosyl-L-methionine (SAM) as the methyl donor. Mammalian development requires proper function of all major DNMT enzymes. Aberrant activity or mutation within DNMT genes leads to various diseases including cancer. Demethylating agents have therapeutic potential.
- Other names
- DNMTm5C DNMTm4C DNMTm6A DNMT
02
Mechanism of action
Catalyzes the transfer of a methyl group to DNA, primarily at cytosine or adenine bases, using S-adenosyl-L-methionine (SAM) as the methyl donor.
03
Biological functions
Gene regulationGenomic imprintingX-chromosome inactivationSuppression of transposable elementsDNA methylationEpigenetic regulationGenome stability
04
Disease associations
CancerImmunodeficiencyChromosomal instabilityAgingICF Syndrome
05
Safety considerations
Potential for off-target effects with demethylating agents.Altered body-wide gene expression patterns
06
Interacting drugs
5-aza-deoxycytidine
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