DNA Methyltransferase 1 ()

DNA Methyltransferase 1 Overview

DNA Methyltransferase 1 (DNMT1) is a key enzyme responsible for maintaining DNA methylation patterns during cell division. It catalyzes the transfer of methyl groups to cytosine residues in CpG dinucleotides, primarily ensuring that newly synthesized DNA strands retain the same methylation pattern as the parent strand after replication. Aberrant expression or mutation leads to abnormal DNA methylation patterns associated with cancer development and developmental disorders. Several compounds have been identified as potential inhibitors targeting DNMT1’s enzymatic function for therapeutic applications.

Mechanism of Action

Inhibition of DNA methylation

Biological Functions

Safety Considerations

Interacting Drugs