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Target intelligence / Profile preview
DNA Methyltransferase 1
- Molecular classification
- Enzyme, DNA methyltransferase
01
Overview
DNA Methyltransferase 1 (DNMT1) is a key enzyme responsible for maintaining DNA methylation patterns during cell division. It catalyzes the transfer of methyl groups to cytosine residues in CpG dinucleotides, primarily ensuring that newly synthesized DNA strands retain the same methylation pattern as the parent strand after replication. Aberrant expression or mutation leads to abnormal DNA methylation patterns associated with cancer development and developmental disorders. Several compounds have been identified as potential inhibitors targeting DNMT1’s enzymatic function for therapeutic applications.
02
Mechanism of action
Inhibition of DNA methylation
03
Biological functions
Maintenance of DNA methylationGene silencingRegulation of lipid and protein reactionsNeurotransmitter signalingNeuron differentiationNeuron survivalEpigenetic inheritance
04
Disease associations
CancerDevelopmental disorders
05
Safety considerations
Potential for off-target effects due to widespread role in epigenetic regulation
06
Interacting drugs
DNMT1 inhibitors (unspecified, >15 compounds)
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