DNA methyltransferase 1-associated protein 1 (DMAP1)

DNA methyltransferase 1-associated protein 1 (DMAP1) is a chromatin-associated regulatory protein encoded by the DMAP1 gene in humans. DMAP1 acts as a subunit of various protein complexes involved in the repression and activation of transcription, frequently through its interaction with DNA methyltransferase 1 (DNMT1) during DNA replication. By engaging with DNMT1, histone deacetylase 2, and other chromatin regulators, DMAP1 can modulate DNA methylation, histone acetylation, and heterochromatin formation, thereby influencing the maintenance of epigenetic states and proper cell cycle progression. DMAP1 is also a key member of the nucleosome acetyltransferase of H4 (NuA4) complex, which plays important roles in transcriptional activation and DNA repair. Dysregulation of DMAP1-related pathways is associated with oncogenesis and other diseases due to epigenetic silencing or activation of specific genome regions.

Other names

KIAA1425DNMAP1DNMTAP1EAF2MEAF2SWC4FLJ11543

Not applicable; since DMAP1 is not a primary drug target, no mechanisms of action for drugs are defined for DMAP1. Its modulatory or co-factor activity could, however, affect epigenetic drugs targeting partners such as DNMT1 or HDACs via indirect modulation.