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DNA methyltransferase 2 homolog
- Molecular classification
- Enzyme, RNA methyltransferase, DNA methyltransferase homolog
01
Overview
DNMT2/TRDMT1 is the most conserved member of the DNA methyltransferase (DNMT) family. Primarily acts as an RNA methyltransferase, specifically modifying tRNA^Asp (aspartic acid transfer RNA); specifically methylates cytosine 38 in the anticodon loop. It maintains stability and function of certain tRNAs by catalyzing their cytosine modification. Recent research suggests possible roles for DNMT2/TRDMT1 mutations or altered activity in cancer biology.
- Other names
- DNMT2TRDMT1
02
Mechanism of action
Cytosine-C5 RNA/tRNA-specific methylation
03
Biological functions
tRNA methylationtRNA stabilityProtein synthesis regulation
04
Disease associations
Cancer
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