Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
DNA Methyltransferase 3 Beta (DNMT3b)
- Target
- DNMT3b
- Molecular classification
- Enzyme, DNA Methyltransferase
01
Overview
DNA Methyltransferase 3 Beta (DNMT3b) is an enzyme that belongs to the family of DNA methyltransferases, responsible for adding methyl groups to cytosine residues in DNA, a key epigenetic modification that regulates gene expression. DNMT3b primarily functions as a *de novo* methyltransferase, establishing new DNA methylation patterns during development. Mutations in the DNMT3B gene are associated with immunodeficiency-centromeric instability-facial anomalies syndrome (ICF syndrome), and variants may contribute to other conditions such as nicotine dependency and cancer.
02
Mechanism of action
Inhibition of DNA methylation
03
Biological functions
DNA methylationGene expression regulationEmbryonic developmentImprintingX-chromosome inactivationTranscriptional silencingAlternative splicing regulation
04
Disease associations
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome (ICF syndrome)CancerNicotine dependency
05
Safety considerations
Aberrant DNA methylation leading to developmental defectsPotential for off-target effects due to widespread epigenetic changesTumor heterogeneity
Beyond the preview
Go deeper on DNA Methyltransferase 3 Beta (DNMT3b).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on DNA Methyltransferase 3 Beta (DNMT3b).