DNA Minor Groove at GC-Rich Sequences (GC-rich minor groove)

The DNA minor groove at GC-rich sequences is a region of the DNA double helix characterized by a wider groove width and a distinct chemical environment compared to AT-rich regions. The presence of guanine-cytosine base pairs and the 2-amino group on guanine significantly influence its structure and interactions with proteins and small molecules. These regions are often found near gene promoters and are involved in transcriptional regulation, chromatin structure, recombination rates, and genome stability. While some drugs can bind to the minor groove, specific targeting of GC-rich regions remains challenging due to steric hindrance and differences in electronegativity.

Other names

GC-minor grooveG/C minor grooveMinor groove of GC-rich DNA

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