Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
DNA mismatch repair (MMR)
- Target
- MMR
- Molecular classification
- Other (multienzyme DNA repair pathway; not classified as enzyme, receptor, transporter, channel, or transcription factor)
01
Overview
DNA mismatch repair (MMR) is a highly conserved, multi-protein pathway responsible for detecting and correcting mismatches and small insertion/deletion loops resulting from DNA replication errors or recombination, ensuring the fidelity of genetic information. The pathway involves recognition (MutS/MutL homologs in eukaryotes), excision, resynthesis, and ligation steps. MMR defects lead to microsatellite instability, predisposition to certain cancers (notably Lynch syndrome/colorectal cancer), and have important roles in DNA damage response, meiosis, and suppression of recombination between divergent DNA sequences.
- Other names
- MMRmismatch repair pathwayDNA mismatch repair system
02
Biological functions
Genomic stability maintenanceDNA repairDNA damage responseSuppression of recombination between divergent sequencesPromotion of proper meiosis
03
Disease associations
Cancer (notably hereditary nonpolyposis colorectal cancer / Lynch syndrome and sporadic tumors)Genome instability disordersNeurological and neurodegenerative disease (via trinucleotide repeat expansion syndromes)Sterility and meiosis defects
04
Safety considerations
Increased mutagenesis and carcinogenesis with deficiencyChemotherapy resistance or hypermutator status in deficient tumors
05
Biomarkers
Loss of nuclear expression of mismatch repair proteins (e.g., MLH1, MSH2, MSH6, PMS2) by immunohistochemistryMicrosatellite instability (MSI-high status) as a genomic biomarker
Beyond the preview
Go deeper on DNA mismatch repair (MMR).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on DNA mismatch repair (MMR).