DNA of malignant hepatocyte

The genetic material inside malignant hepatocytes serves as the functional substrate for cytotoxicity induced by localized delivery and decay-mediated emission from yttrium‑90 during radioembolization therapy. Beta particles from Y‑90 cause irreparable damage primarily through induction of single and double-stranded breaks in tumor nuclear DNA[5], resulting in loss-of-function mutations and ultimately triggering apoptosis or necrosis preferentially in rapidly dividing hepatic malignancies while sparing most normal tissue due to limited penetration depth[2][4].

Other names

DNA of liver cancer cellTumor cell DNA (liver)

Induction of double-strand breaks via beta irradiation leading to tumor cell death