DNA polymerase alpha 2 accessory subunit (POLA2)

DNA polymerase alpha 2 accessory subunit (POLA2) is a non-catalytic, accessory protein component of the DNA polymerase alpha complex, a key multisubunit enzyme essential for the initiation of eukaryotic DNA replication. POLA2 forms a stable heterodimer with the catalytic subunit (POLA1) and serves as a structural and regulatory scaffold, mediating recruitment of the polymerase–primase complex to replication forks, and facilitating primer synthesis and early DNA strand extension[1][2][4]. POLA2 is crucial for both the initiation of DNA synthesis and for telomere C-strand maintenance. Pathogenic variants in POLA2 can cause developmental disorders with short telomeres, and its malfunction may contribute to broader replication stress-associated diseases[2][4]. While there are no drugs directly targeting POLA2, its central role in DNA replication makes it of fundamental interest for understanding genome duplication and maintenance.

Other names

DNA polymerase alpha subunit BFLJ21662DNA polymerase alpha 70 kDa subunitpolymerase (DNA-directed) alpha 2 (70kD subunit)polymerase (DNA) alpha 2 accessory subunitDPOA2