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Target intelligence / Profile preview
DNA polymerase alpha catalytic subunit A (POLA1)
- Target
- POLA1
- Molecular classification
- Enzyme, DNA Polymerase
01
Overview
DNA polymerase alpha catalytic subunit A is the core enzymatic component of the DNA polymerase alpha (Pol α) complex, essential for initiating DNA replication in eukaryotic cells. It synthesizes short DNA fragments on both leading and lagging strands, handing off to other polymerases for elongation. POLA1 interacts with several proteins involved in replication fork progression and cell cycle regulation. Aberrant function can contribute to genome instability and disease.
- Other names
- p180 subunit of DNA polymerase alphaDNA polymerase alpha catalytic subunitPOLA1
02
Mechanism of action
DNA polymerase alpha inhibitors (not specific to human POLA1)
03
Biological functions
DNA replication initiationRNA primer extensionOkazaki fragment synthesisDNA synthesisGenome maintenance
04
Disease associations
CancerGenome instability-related diseasesImmune dysregulation
05
Safety considerations
Potential for off-target effects on other polymerasesDisruption of DNA replication leading to cell deathImmune activation
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