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Target intelligence / Profile preview
DNA polymerase alpha subunit B (POLA2)
- Target
- POLA2
- Molecular classification
- DNA Polymerase Subunit, Regulatory Protein
01
Overview
DNA polymerase alpha subunit B is a non-catalytic, regulatory component of the eukaryotic DNA polymerase alpha-primase complex, essential for initiating DNA replication. It stabilizes the catalytic core, regulates cell cycle-dependent activity, acts as a scaffold for protein-protein interactions within the replication machinery, and mediates recruitment to origins of replication.
- Other names
- POLA2p70 subunit of DNA polymerase alphaDNA polymerase alpha 70 kDa subunit
02
Biological functions
DNA replication initiationProtein-protein interaction scaffoldingOrigin of replication recruitmentCell cycle regulationStabilization of DNA polymerase alpha complex
03
Disease associations
CancerGenetic disorders related to DNA replication
04
Safety considerations
Inhibition may disrupt DNA replication and cell divisionPotential for off-target effects on other DNA polymerases
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