Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
DNA Polymerase Beta (None)
- Target
- None
- Molecular classification
- Enzyme, DNA Polymerase
01
Overview
DNA polymerase beta (Pol β) is a small, essential eukaryotic enzyme primarily involved in the base excision repair (BER) pathway, which is crucial for repairing damaged DNA and maintaining genome stability. It consists of two main domains: an N-terminal 8 kDa domain with 5′-deoxyribose phosphate (dRP) lyase activity and a C-terminal 31 kDa domain with DNA polymerase activity. Pol β plays a central role in BER by excising damaged bases and filling in resulting single-nucleotide gaps with new nucleotides. Levels of Pol β decline with age in various tissues, correlating with decreased BER capacity and increased accumulation of DNA damage. Pol β can be inhibited by certain chemotherapeutic agents, and inhibiting it may sensitize cells to DNA-damaging agents used in cancer therapy.
- Other names
- POLB
02
Mechanism of action
Inhibition of DNA Polymerase Beta
03
Biological functions
Base excision repairGap-filling synthesisdRP lyase activityGenome maintenanceDNA repair
04
Disease associations
CancerAging
05
Interacting drugs
Fludarabine triphosphate (F-ara-ATP)
Beyond the preview
Go deeper on DNA Polymerase Beta (None).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on DNA Polymerase Beta (None).