DNA polymerase delta subunit 2 (POLD2)

DNA polymerase delta subunit 2 (POLD2) is the 50-kDa accessory subunit of the DNA polymerase delta complex, which is essential for high-fidelity DNA replication and repair. As a non-catalytic component, POLD2 stabilizes the holoenzyme, promotes processivity through interaction with the proliferating cell nuclear antigen (PCNA), and is involved in both lagging and leading strand synthesis. It is also a component of the DNA polymerase zeta complex, supporting translesion synthesis and various DNA repair pathways, including nucleotide excision repair. Mutations or altered expression of POLD2 are linked with increased genomic instability and cancers. Small molecule inhibitors such as cytarabine target DNA synthesis, exploiting POLD2 function for therapeutic benefit, particularly in oncology[1][3][5][6][7].

Other names

DNA polymerase delta 2, accessory subunitPOLD2DNA polymerase delta subunit p50Pol delta B subunit (p50)polymerase (DNA directed), delta 2, accessory subunitpolymerase (DNA directed), delta 2, regulatory subunit 50kDaDNA polymerase δ 2, accessory subunitp50po1D2

Inhibition of DNA synthesis by nucleoside analog incorporation, leading to selective toxicity in replicating cells