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DNA polymerase epsilon (None)

Target: None
Molecular classification: Enzyme, DNA polymerase

Overview

DNA polymerase epsilon is a multi-subunit enzyme responsible primarily for leading-strand synthesis during eukaryotic chromosome replication. It combines high-fidelity catalysis with crucial structural roles within the replisome complex—functions that are indispensable not only for accurate genome duplication but also coordination between replication progression, chromatin dynamics, checkpoint activation, and multiple forms of post-replicative repair.

Other names: Pol εPOLEPOL2

Mechanism of action

DNA synthesis inhibition via nucleotide misincorporation or chain termination. Exonuclease activity inhibition.

Biological functions

DNA replicationLeading strand synthesisDNA repairNucleotide excision repair (NER)Base excision repair (BER)RecombinationCheckpoint signalingGenome stability maintenanceChromatin dynamics

Disease associations

Cancer

Safety considerations

Loss of key non-catalytic domains can lead to lethality

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