DNA polymerase epsilon catalytic subunit (POLE)

DNA polymerase epsilon catalytic subunit (POLE) is the central catalytic component of the DNA polymerase epsilon complex, a multi-subunit enzyme essential for leading strand DNA synthesis during replication in eukaryotes[1][2][3][4][5][7]. POLE possesses intrinsic 3'-5' exonuclease activity, enabling proofreading to reduce replication errors. It also contributes to various DNA repair pathways, including base excision and nucleotide excision repair, maintaining genomic stability. Germline or somatic mutations in POLE are linked to cancer predisposition (especially colorectal and endometrial cancer) and rare syndromic disorders characterized by developmental anomalies and immunodeficiency[2][5]. As an enzyme critical for cell proliferation and DNA integrity, POLE is investigated as a potential therapeutic target and biomarker, although no approved drugs directly targeting POLE are available[2][5].

Other names

DNA polymerase epsilon catalytic subunit APOLE1DNA polymerase II subunit ACRCS12FILSDPOE1

No approved drugs currently target POLE. Experimental inhibition may involve blocking catalytic/exonuclease function.