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DNA Polymerase II (None)
- Target
- None
- Molecular classification
- Enzyme, DNA Polymerase
01
Overview
DNA polymerase II (Pol II) is a prokaryotic DNA-dependent DNA polymerase primarily involved in DNA repair and acts as a backup enzyme for the main replicative polymerase, DNA polymerase III, in *Escherichia coli*. It catalyzes phosphodiester bond formation between nucleotides during both normal replication (as backup) and repair synthesis. It possesses 5'→3' polymerase activity and 3'→5' exonuclease (proofreading) activity. Its processivity is enhanced by interaction with accessory proteins such as the β-clamp and clamp loader complex.
- Other names
- Pol IIpolB gene product
02
Mechanism of action
Inhibition of DNA synthesis through competitive or non-competitive mechanisms
03
Biological functions
DNA replication (backup)DNA repairProofreading
04
Disease associations
Response to DNA damageMutagenesis (indirectly)
05
Safety considerations
Potential for off-target effects on other DNA polymerasesInduction of mutations if repair function is compromised
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