Target intelligence / Profile preview

DNA polymerase III PolC (None)

Target: None
Molecular classification: Enzyme, Polymerase, C family DNA polymerase

Overview

DNA polymerase III PolC is a replicative DNA polymerase found in many Gram-positive bacteria. It is essential for genome duplication and is the primary enzyme responsible for high-fidelity, processive DNA synthesis during bacterial cell division. The enzyme also exhibits 3' to 5' exonuclease activity, which provides proofreading capability to ensure accurate DNA replication. Its unique structural features make it an attractive target for antibacterial drug development because inhibiting PolC can halt bacterial proliferation without affecting eukaryotic host cells.

Mechanism of action

Inhibition of DNA replication

Biological functions

DNA replicationDNA repairProofreadingChromosomal replication

Disease associations

Infection

Safety considerations

Potential for off-target effects if inhibitors are not specific to bacterial PolC.

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