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DNA polymerase III subunit C (None)
- Target
- None
- Molecular classification
- Enzyme subunit, Clamp loader component
01
Overview
DNA polymerase III subunit C (HolC/Chi) is a component of the DNA polymerase III holoenzyme in bacteria such as *Escherichia coli*. It plays a critical role in the clamp loader complex, facilitating the loading of the beta sliding clamp onto primed DNA to enable processive DNA synthesis. While not directly catalytic, it stabilizes interactions within the clamp loader and with other replication proteins.
- Other names
- Chi subunitHolC
02
Mechanism of action
Inhibiting bacterial replication
03
Biological functions
DNA replicationBeta-clamp loadingStabilizing protein interactions
04
Disease associations
Infection
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