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DNA Polymerase IIIC (polIIIC)

Target: polIIIC
Molecular classification: Enzyme, DNA Polymerase, C-family replicative DNA polymerase

Overview

DNA Polymerase IIIC (polIIIC) is a bacterial DNA polymerase essential for chromosomal replication in Gram-positive bacteria such as Bacillus subtilis. It belongs to the C-family of DNA polymerases and catalyzes the 5'→3' synthesis of new DNA strands while possessing 3'→5' exonuclease activity for proofreading. As it is unique to prokaryotes (specifically certain bacterial lineages), it presents a potential target for narrow-spectrum antibiotics.

Other names: polC

Mechanism of action

Inhibition of DNA synthesis

Biological functions

DNA replicationProofreadingGenome duplication

Disease associations

Infection

Safety considerations

Potential for off-target effects if inhibitors are not highly specificDevelopment of resistance by bacteria

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