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Target intelligence / Profile preview
DNA Polymerase Inhibition by Nucleoside Analog Incorporation (NA)
- Target
- NA
- Molecular classification
- Enzyme, DNA Polymerase, Reverse Transcriptase
01
Overview
Inhibition of DNA polymerases and/or reverse transcriptases through the incorporation of nucleoside analogs into nascent DNA strands, leading to chain termination and disruption of DNA synthesis. This is a common mechanism of action for many antiviral and anticancer drugs.
- Other names
- Nucleoside Analog IncorporationDNA Synthesis Enzyme InhibitionDNA Polymerase InhibitionReverse Transcriptase Inhibition by Nucleoside Analogs
02
Mechanism of action
Competitive substrate mimicry of natural nucleotides, leading to chain termination during DNA synthesis by DNA polymerases and reverse transcriptases upon incorporation into the DNA strand.
03
Biological functions
DNA replicationGenome duplicationCell cycle regulationApoptosis inductionViral replication
04
Disease associations
CancerViral infections
05
Safety considerations
MyelosuppressionDrug resistanceOff-target effects on host cell DNA replication
06
Interacting drugs
Cytarabine
5 more in the full profile.
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