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Target intelligence / Profile preview
DNA Polymerase Theta (Pol θ)
- Target
- Pol θ
- Molecular classification
- A-family Polymerases, Enzyme
01
Overview
DNA polymerase theta is an error-prone eukaryotic enzyme encoded by the *POLQ* gene that plays an essential role in repairing double-strand breaks through the mutagenic TMEJ/MMEJ pathway. Its unique structure combines a helicase-like domain with an A-family polymerase lacking proofreading ability. While crucial for genome stability under stress conditions, its overexpression supports tumor cell survival when canonical DSB pathways fail, making it both a biomarker of poor prognosis and an emerging therapeutic target—especially relevant where homologous recombination defects exist.
- Other names
- POLQ
02
Mechanism of action
Inhibition of POLθ polymerase activity, blocking TMEJ/MMEJ-mediated DSB repair
03
Biological functions
Double-strand break repairDNA synthesisTranslesion synthesisReverse transcriptionGenome maintenance
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects on other polymerasesDevelopment of resistanceImpact on normal DNA repair processes
06
Interacting drugs
RP‑6685
07
Biomarkers
High POLQ expression in tumorsHomologous Recombination Deficiency (HRD)
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